منابع مشابه
Efficient mitochondrial targeting relies on co-operation of multiple protein signals in plants
To date, the most prevalent model for transport of pre-proteins to plant mitochondria is based on the activity of an N-terminal extension serving as a targeting peptide. Whether the efficient delivery of proteins to mitochondria is based exclusively on the action of the N-terminal extension or also on that of other protein determinants has yet to be defined. A novel mechanism is reported here f...
متن کاملPrediction of Mitochondrial Targeting Signals Using Hidden Markov Model.
The mitochondrial targeting signal (MTS) is the presequence that directs nascent proteins bearing it to mitochondria. We have developed a hidden Markov model (HMM) that represents various known sequence characteristics of MTSs, such as the length variation, amino acid composition, amphiphilicity, and consensus pattern around the cleavage site. The topology and parameters of this model are autom...
متن کاملRedundant mitochondrial targeting signals in yeast adenylate kinase.
Yeast adenylate kinase (Aky2p, Adk1p) occurs simultaneously in cytoplasm and mitochondrial intermembrane space. It has no cleavable mitochondrial targeting sequence, and the signal for mitochondrial import and submitochondrial sorting is largely unknown. The extreme N terminus of Aky2p is able to direct cytoplasmic passengers to mitochondria. However, an Aky2 mutant lacking this sequence is imp...
متن کاملA morphological view on mitochondrial protein targeting.
Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and synthesized in the organellar matrix. These include predominantly inner membrane proteins that are perhaps co-translationally inserted into th...
متن کاملDifferent legumin protein domains act as vacuolar targeting signals.
Legumin subunits are synthesized as precursor polypeptides and are transported into protein storage vacuoles in field bean cotyledons. We expressed a legumin subunit in yeast and found that in these cells it is also transported into the vacuoles. To elucidate vacuolar targeting information, we constructed gene fusions of different legumin propolypeptide segments with either yeast invertase or c...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 1988
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst0160709